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10.06.2018

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  • in denver sale oils for cbd
  • Colorado Marijuana Growers Diversify With Hemp Amid CBD Boom
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  • That is, if people can figure out how to buy CBD oil and concentrates. Most often used for medical reasons, these products can be purchased. Reviews on Cbd Oil in Denver, CO - Kind Love Dispensary, Alternative Medicine on Capitol Hill “Buy my CBD oil here and the service is prompt and helpful. Buy hemp CBD oil, e-juice, tincture, capsules, edibles & more. Free shipping on orders over $99 to all 50 states. Discover the natural benefits of cannabidiol.

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    Dispensaries Obviously, you can only do this in a state where commercial marijuana is legal, but if you're lucky enough to live in such a place, dispensaries are your best option for in-person retail. Why is it worth a trip to a dispensary? On top of the added medical benefits of THC, CBD oil derived from marijuana, not hemp, has been shown to be of better quality and likely have a slower rate of increased tolerance. In Colorado, the efficacy of hemp-derived CBD isn't regulated by a state agency, while dispensaries must have all of their products lab-tested for contaminants and potency.

    Head Shops No dispensaries in your state? Even in states where recreational pot is legal, many head shops carry a variety of medical and recreational CBD products. If you come across a store down with the cause, your options will largely be vaporizable concentrates, such as CBD oils in pre-filled cartridges and purified CBD isolate, which can reach upwards of 99 percent purity.

    Some smoke shops also carry CBD tinctures, topicals and even foods. Health Food Stores and Wellness Boutiques Boutiques and shops that focus on wellness, healthy eating and alternative healing don't carry CBD products as frequently as head shops, but when they do, staffers are generally more knowledgeable and can provide more detailed advice about what might help with anxiety, pain, skin conditions and so on.

    Just be sure not to confuse hemp-seed products — a common fixture at health-focused stores — with CBD. They aren't the same. Flora's even hosts events with free hemp tea and educational speakers at the end of each month.

    You have successfully signed up for your selected newsletter s - please keep an eye on your mailbox, we're movin' in! Online The easiest and most convenient way to buy CBD products is online — and you don't have to worry about the Drug Enforcement Administration breaking down your door, despite the ambiguity surrounding CBD's legality.

    She and her husband fell into debt, in part because of medical bills before Preston qualified for Medicaid. Their marriage collapsed under the stress, and Ana moved back in with her parents. She tried working full time, then cut back to part time.

    And in some ways, that was worse than not knowing at all because it meant there was no cure to find. Robert Greenwood hustled into the meeting room wearing a tie covered with Dr. As a pediatric neurologist, Greenwood had treated hundreds of kids with epilepsy in his year career. At times, he could walk down the hall and you could see 10 to 20 seizures happening, little jerks.

    So he was literally having seizures all of the time. Some epilepsies respond well to generalized anti-seizure drugs. Preston has at least four different kinds of seizure types, and they varied in severity and frequency as he grew older. Ana is visiting from North Carolina to change her residency and apply for a medical marijuana red card for Preston. There are the grand mals, known clinically as tonic-clonic seizures, that are full of violent convulsing that can last minutes.

    Preston falls into one about once a week. But much more common are the little eye flutters. In medical terms, they are called myoclonic seizures. He can have hundreds of blinkies a day. Over and over, new development is wiped clean by the seizures. So, over and over, he learns the same things. At 12 years old, Preston cannot spell his name. He cannot reliably count to He is still learning his colors. He wobbles when he walks and falls over easily. Myoclonic seizures Brief seizures characterized by little muscle jerks.

    Sometimes, Greenwood and Ana would find a medicine that worked for Preston. The seizures would lessen and Preston would start to walk more steadily. Sitting in the hospital meeting room, Greenwood said there was little more he could do for Preston with the medicines available. It was about a month before the move away from their little brick house in Greensboro, N.

    Sydney was already there. When Ana woke before dawn, she was nestled between children. Once begun, the morning ticked along with practiced precision. Ana made the fried potatoes Preston only ever wants for breakfast. Eight-year-old Sydney quietly dressed and got ready on her own, until it was time to ask mom to fix her ponytail.

    Finally dragging Preston from bed, Ana sat him in his skull-and-crossbones pajamas in front of the television and turned on a video of Barney the dinosaur. Sydney walked by and scrunched up her face. She had already outgrown Barney. But Preston watched rapturously, planting his elbows onto his knees and his head into his hands. His eyes are a deep walnut color and are framed by long eyelashes.

    Brown hair swirls atop his head in casual rebellion. His smile is all in the top lip, pulling up past his gum line to reveal a row of glimmering teeth. The first seizure of the day had come and gone. July 11 Sydney Watson, 8, tries to get older brother, Preston, to drink some sweet tea. Over the fireplace hung a photo of Preston in a straw cowboy hat. His mouth is closed and his eyes set in a stoic glare, and he appears startlingly mature — a boy trying to look like a man trying to look like a rock star.

    There are times, Ana said, when she can almost see what Preston could become if the seizures would just let him. Everyone in her family has their own vision of what Preston might be. Ana tries to keep her daydreams in check.

    But there is one thing she hears the parents of Dravet children often say, and, yes, she hesitantly admitted, she would like it, too. The documentary about Charlotte Figi aired the next summer , and by late — as Preston approached his 12th birthday stuck in the same developmental rut he had been in for his previous nine — the online whispers of a marijuana miracle in Colorado had turned into a roar.

    The hope tugged at her. The closer the move came, the worse Preston seemed to get. He suffered another grand mal returning from a last-second beach getaway. He grew reluctant to eat or drink, which left him not only weak but also not getting the right dose of conventional medicine hidden in his food. In advance of the move, Ana reduced the dose of one of the three main seizure medicines he takes — a drug called Onfi — because she had heard from other parents that CBD amplifies it.

    For all of the parents asking him about moving to Colorado — Ana was not the first — Greenwood had told them the same thing: When he looked at the exodus of families heading to Colorado, Greenwood worried about the people who might prey on their desperation. But he also worried about the enthusiasm that might spring from their hope.

    He had warned Ana strongly against taking Preston off his other seizure drugs. Drool dribbled off his chin and onto his T-shirt. Milly, who was watching him while Ana packed up the last things, sensed a bigger seizure building. She fanned Preston, hoping to calm the blinking.

    Twelve days of waiting. Twelve days of seizing. Twelve days of wondering what would happen. She has had to fill out many forms and file a change-of-patient record for the medical marijuana registry.

    She now is overwhelmed with worries: She had to wait another three days after picking up the oil for a lab report to come back to confirm its potency.

    When the day of the first dose finally arrived, in mid-July, Ana bounded into the kitchen of her new home to pull a bottle of the oil from the fridge.

    Holding the bottle of amber-colored oil in her hand, she scanned the report to figure out how much she should give Preston. But the report was indecipherable. How could she convert these numbers into the recommended dose? Walking toward him, she had no idea of the frustration ahead, and no inkling of the discomfort she would inflict on them both in her effort to bring relief.

    All she knew as she looked toward her seizing son was that she held in her hands the latest, best chance to move his life forward. An hour-and-a-half later, as Preston quivered on her lap in the bathroom following the first dose, she realized this journey would be tougher than she hoped.

    Ana visited Colorado ahead of moving her family from North Carolina to change her residency and apply for a medical marijuana red card for Preston. The migration to Colorado by families of sick children seeking medical marijuana is fueled by hope, not science. The doctor ticks through 13 different medicines, but Preston has already tried each one, to little effect.

    August 20 Ana Watson gets a firsthand view of the trimming and drying process that goes into making the CBD oil she is using to treat her son, Preston. They fit in a medium-sized hotel meeting room They fit in a medium-sized hotel meeting room. Because of the complexity of the human brain, epilepsy drug development is a sparse field. In , there were 28 anti-seizure drugs in some stage of clinical trials in the United States, according to the pharmaceutical industry group PhRMA. But the genetic variability and rarity of Dravet syndrome makes the disease especially difficult for drug companies.

    It could cost hundreds of millions of dollars for a pharmaceutical company to get a drug all the way through federal approvals and onto the market to treat that little pocket of patients. Because of those challenges, the drugs being developed for Dravet syndrome all have a certain this-is-just-crazy-enough-to-work quality.

    At the conference, drug rep after drug rep stepped to the microphone to discuss the forthcoming products. And, not coincidentally, two drug companies at the conference presented plans to bring CBD-based drugs to market. Surrounded by physicians and Ph. She talked about wanting to start clinical trials on Colorado-made CBD products. She tried to tamp down hype. This is just a new seizure treatment. So, the entire day after that first dose, Ana watched Preston like a poker player looking for a tell.

    Did that mean the marijuana made him sleepy? Did the extract make him hungry? Then the next day, Preston suffered a grand mal seizure that left him writhing violently. He had another one the day after that. Ketogenic diet , the doctor asks?

    July 29 Preston meets Dr. Alan Shackelford at his office in Denver. Even as families flock to the state, few doctors here condone the use of marijuana to treat seizures. And that means the very people on whom families depend for medical advice are often silent when it comes to critical questions about the new treatment.

    The state health department, which manages the patient registry that all children using medical marijuana must join, offers almost no guidance.

    About kids who see doctors at the hospital have tried a CBD treatment. A national survey of doctors by the American Epilepsy Society found that while 94 percent said they have been asked by a patient about using cannabis to control seizures, fewer than a third would actually recommend that patients try it.

    Another 13 percent said they would support its use but would rather have another doctor provide the recommendation needed to obtain it. In a lab in Seattle, black mice twitch uncontrollably as they work their way through an electrified cage, furry little avatars of kids with Dravet syndrome In a lab in Seattle, black mice twitch uncontrollably as they work their way through an electrified cage, furry little avatars of kids with Dravet syndrome.

    The mice were created in the lab of William Catterall, a University of Washington pharmacologist whose work on the brain has seen him mentioned as a Nobel Prize candidate. These genetically engineered mice are providing answers to stubborn questions about the causes of Dravet syndrome. But they are also providing confirmation of how hard the cure will be to find. For years after French doctor Charlotte Dravet described her namesake disease, researchers were at a loss to explain what caused it.

    Halfway around the world, Catterall and his colleagues were coming up with an answer. A brain nerve cell, or neuron, is like a spark plug, shooting a signal out to other cells to start a task. Genetic mutations in the sodium ion channel can create funky electrical activity in the brain, something Catterall knew could apply to epilepsy research. In , the year Preston was born, a team of researchers in Belgium proved him right.

    They identified a specific sodium channel gene , known as SCN1A , in which almost all Dravet patients have a mutation.

    Typically, the two work in conjunction. Excitatory neurons promote a function. Inhibitory neurons stop it. Catterall likens it to having green lights in every direction for downtown traffic. Basically, the brains of Dravet patients are all gas and no brakes. The discovery helped doctors eliminate some types of medicines they had been prescribing to Dravet patients and unintentionally making seizures worse.

    But it still left a challenge. The SCN1A mutation is almost never inherited. Some respond well to certain drugs. Meanwhile, a Dravet patient in Australia named Dannielle Goodwin has held a job, lived on her own and is now raising three children. Catterall said more research is planned, and he has a proposal to study how CBD might work on his mice.

    The result of that one-sided conversation, though, is that parents who give CBD to their children must turn to one another and their medical marijuana providers for help. By not engaging more with providers, doctors often lack an understanding of the types of marijuana products their patients are using and are unaware of the sometimes contradictory advice their patients receive.

    For instance, CBD providers commonly tell newly arrived parents that they should reduce the level of an anti-seizure drug called Onfi before starting CBD because the two could have a dangerous interaction.

    Parents often reduce the medicine without consulting with their doctors. Meager research makes it impossible to know who is right. He will soon have a feeding tube inserted into his stomach, allowing Ana to give him food and medicine consistently. May 8 The dregs of his afternoon seizure medications are still on his lips as Preston rests on his porch after a long day of school interrupted by numerous myoclonic seizures.

    May 8 Ana Watson has to keep a tight rein on her son, Preston, as they head off to school. May 11 As the furniture slowly empties from the house, Preston, complete with safety goggles and boots, plays carpenter in the dining room while whirling dervish little sister Sydney practices handstands and walkovers in the new space.

    The vest keeps his core temperature even. May 12 Preston pulls back toward the lunchroom with Regina Lane, his in-school nurse, as he hears a friend in the hallway. Regina has been with Preston for five years. She knows that if something catches his attention, he will head in that direction. She also knows how to persuade him to focus on what he might be doing. May 12 Preston spits out his seizure medications, which were mixed with sweet tea. He took the first few squirts easily, but as more of the undissolved pills filled the syringe, the taste and texture became much worse.

    But all attempts are less and less effective. June 18 A few days before moving to Colorado in search of new treatments for Preston, Ana takes the family to the shore in North Carolina for a short vacation. June 27 Ana Watson holds her son, Preston. He wants to look out the big window and see the miles go by in their new state but is being hit by clusters of myoclonic seizures.

    Don reads everything very carefully: He is worried about Ana being so far from home and whether her income will cover everything she and the kids will need. July 1 Things are looking up at the RV park.

    Ana has found a house she wants to rent, and Preston found a computer chair he likes set out for free near the trash bin. June 30 Ana Watson blocks the door to keep Preston inside during an interview to evaluate the type and amount of care he will need in Colorado. He knows she is trying to give him his afternoon medications; after years of this working for their family, Preston has stopped falling for the ruse and fights it every time.

    Finally, he is able to help unload the trailer, which has held his complete attention as it followed his family across the country on the trip to Colorado. With most of the moving and assembling done, Don will be leaving his daughter and grandson in the morning for the long ride back to North Carolina. Preston has refused to take his meds without a fight for a solid week, and everyone is worried and exhausted by the efforts to get him to take them.

    He spit them all out. July 7 Preston, curious about everything, watches his new pediatrician, Dr. July 12 Preston watches as Ana and her mother, Milly Raynor, argue over how to administer the CBD oil after Preston spit out their first attempt at giving it to him orally. He needs to take it. For weeks he has not been eating well or getting his full amount of seizure medications.

    Preston went in for an appointment to meet his neurologist that turned into an operation for a gastrostomy tube and a hour EEG. July 23 An absent seizure looks and feels just like it sounds: Preston stopped interacting, staring into nothing, drool leaking from his mouth, his hands unmoving. Dravet syndrome children experience many types of seizures.

    The seizures can change, and some children will have a combination of seizure types, all during one episode. Preston has been running a fever for three days, today at a steady He has been complaining about his feeding button: They went from the clinic to an X-ray at Memorial Hospital to check the feeding tube placement. July 24 Preston gently touches his friend Hailey McGuire as she rests at his home.

    There is a connection between Dravet mothers, but there also seems to be a deep understanding between Dravet kids. August 5 Preston hides from his mom as she mixes his medications. Preston was playing with a water slide in the back yard when he fell and began to seize. August 6 Preston cries as Milly and his nurse, Chelle Bennett, try to remove his wet clothes and warm him with blankets.

    The pain from a fall while he was playing with a water slide appears to have caused a grand mal seizure. September 3 Ana is trying a new way of giving Preston his oil. She squirted it in and he started spitting and sputtering as soon as he tasted it. She ended up mixing it with formula and using his feeding tube. By using the oil separately she can figure his dosing ratios for tighter control.

    Milly has moved into her own apartment to relieve some of the tension that can arise between her and Ana. She plans to live in Colorado as long as her daughter and the children are here. October 7 Working to improve his hand-eye coordination, Preston concentrates on popping bubbles with one finger during occupational therapy at home with Kate Vovato, a therapist from MGA Home Healthcare.

    October 7 Preston and Haleigh dance while Tami watches in the background. On his 13th birthday, he finally has one of his own, with big training wheels.

    Preston has suffered continuous myoclonic clusters most of the day. He had a second grand mal seizure early in the afternoon. Dravet syndrome children usually have a variety of seizure types, which can change for a number of reasons. A blue line squiggles furiously up and down on a computer screen.

    It is one answer to the question that has vexed Ana for the past 12 years: But, even now, the seizures remain a mystery. Some little eye-flutter seizures cause leaping spikes on the screen. Some seem to skip by without a change in the pattern.

    EEGs are taken by affixing 21 electrical wires — or leads — to standardized positions on the scalp. To doctors concerned about recommending unregulated cannabis products to their patients, the future of medical marijuana is growing in the south of England To doctors concerned about recommending unregulated cannabis products to their patients, the future of medical marijuana is growing in the south of England.

    There, researchers with the drugmaker GW Pharmaceuticals are developing medicines derived from greenhouse-grown cannabis plants — tinctures and mouth sprays to treat everything from muscle spasticity to cancer pain to epilepsy.

    But scientific breakthroughs are not what led GW to develop the drugs. Rather, it was public opinion. The drug, Epidiolex , is now in early clinical trials in the United States. The pattern reveals how hope can leap ahead of research even at the highest levels of drug development. Epidiolex is one of two CBD drugs being developed by pharmaceutical companies to treat pediatric epilepsies, and neither drugmaker has hidden that public interest is behind the creation of the drugs.

    Last summer, at a conference discussing forthcoming epilepsy drugs, Mark Davis with Insys Therapeutics — which is developing a synthetic form of CBD — said his Arizona company still had much to learn about what exactly CBD does.

    Nonetheless, Insys has received special government approval for its CBD product to treat conditions ranging from epilepsy to brain tumors to pediatric schizophrenia. Supporters of pharmaceutical pot say it is consistent, quality-controlled and tested in ways that cannabis grown by medical marijuana providers is not. However, Schultz said GW does not claim to grow its plants organically, something most Colorado medical marijuana growers pride themselves on.

    Roughly more kids at 12 different hospitals in the United States have received Epidiolex through a special program that allows doctors to prescribe experimental drugs to treat rare diseases, Schultz said. But the results from that program show Epidiolex may be effective for only a fraction of patients.

    A study of patients using Epidiolex in New York and California found that about a third of the patients studied had a greater than 50 percent reduction in seizures. At the end of their first visit, Dr. The timing worked; Preston was already in the hospital, after the feeding tube surgery the day before.

    She had spent seven months planning how to get to Colorado for the treatment. His future looks bright again. This version corrects the name of the agency that could approve the first drug derived from CBD. This material may not be published, broadcast, rewritten or redistributed.

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