Published in the journal Epilepsy and Behavior, the results indicate use of CBD AEP decreased from at the beginning of CBD therapy to at the CBD in the near future, it also provides all patients with epilepsy an. A brand of cannabidiol (CBD) was approved in June for treatment of epilepsy by the United States Food and Drug Administration (FDA). In future, double-blind, controlled trials are required and the use of Recent studies have shown an effect of CBD in treating epilepsy (Table 1).
of Treatment Is Epilepsy? Future for the CBD the
Derived from CBD oil refresher: THC is the stuff that gets you high, not CBD , a drug called Epidiolex was just approved to treat seizures in children and adults with two rare but severe forms of epilepsy, both of which typically develop in childhood. Considering the fact that marijuana is still illegal in many states across the U.
Epidiolex is essentially medical-grade CBD oil—a highly concentrated, consistent, and regulated version of the more holistic stuff. Because CBD doesn't get you high, health brands have zeroed in on CBD as an effective way to relieve pain, decrease inflammation, and potentially treat a variety of health conditions—including epilepsy.
But even though the medicinal oil has long been used as an at-home alternative therapy for seizures, neurologists admit that they still aren't quite sure how CBD oil works. Wolf says there's a lot to be excited about with this new innovation and its availability within mainstream medicine.
In addition to the states with legal recreational weed, there are 23 other states where it is legal but only at a medical level. Those 23 states are:. The most recent of these states to legalize medical marijuana were Missouri and Utah, who like Michigan voted to pass it in the midterms.
Oklahoma also voted to legalize medical marijuana earlier in Ohio is also behind schedule, having been unable to meet their goal of having operational dispensaries two years after voting for legalization. The laws in these 14 states can vary widely, but to differing degrees, medical cannabidiol can be allowed for legal use there. Many of these states have very strict rules for who can and cannot get approved for CBD based on what medical condition they have the severity of it.
In , the Senate introduced a new Farm Bill to update laws around the previous one. One important part of that bill, should it pass, is that it would legalize hemp on a federal level. A new, more available form of CBD would also allow for more research on the subject of cannabidiol, and perhaps the entire marijuana plant. Cannbidiol mechanism and structure. Here, we review recent trials that have investigated the use of CBD as a treatment for epilepsy and highlight key issues for future research.
Many patients with epilepsy have wanted to try cannabis as a treatment even though preclinical and clinical evidence is limited. As mentioned above, several clinical studies have investigated CBD after the late 19th century. Recent studies have shown an effect of CBD in treating epilepsy Table 1. They suggest that CBD can reduce the frequency of seizures, reducing monthly frequency in most types of seizures.
Between and , Devinsky et al. They observed enrolled patients for 12 weeks. This study reported a decrease of They observed a decrease of Infantile spasm IS is another epileptic encephalopathy in need of an effective treatment. In , Hussain et al. Regarding the CBD effect on each type of seizure, epileptic spasms and atonic seizures showed the greatest response. The responder rate of tonic-clonic seizures was The rates of complex partial seizures and complex partial seizures with secondary generalization were This study was limited by a small sample size, as well as an uncontrolled and unblinded design, but suggests a potential effect of CBD in TSC.
In previous studies, the most common adverse effect of CBD was drowsiness. Most reported adverse effects were mild, for example diarrhea, fatigue, and decreased appetite. Nonetheless, some more serious effects, including status epilepticus, have been reported. It is interesting that CBD had this severe adverse effect, status epilepticus, because animal studies have not shown any proconvulsant effects of CBD.
CBD also did not affect renal function. Four patients stopped CBD treatment before the end of 12 weeks because of a worsening of seizures or poor efficacy. Most studies suggest anticonvulsant effects of CBD, and consider most adverse effects to be mild. As such, we might expect CBD to show efficacy and safety in the treatment of epilepsy. However, there is potential placebo effects biasing these results.
In a study by Purcarin et al. According to the study of Zaccara et al. A placebo effect is a concern for many studies because of the media attention attracted by CBD, which is likely to interest parents of children with epilepsy.
In most studies, seizure frequency was used as an indicator of efficacy. However, to increase the accuracy of proposed effects, data from clinical tests, such as electroencephalograms, are necessary. Due to the absence of a control group in previous studies, the adverse reactions to CBD may also have resulted from a bias.
For example, many studies reported gastrointestinal problems, such as diarrhea and decreased appetite. However, CBD is usually in the form of oil, which may have precipitated these effects. Therefore, the adverse effects should be reviewed. Furthermore, other adverse effects, such as drowsiness, thrombocytopenia, and elevated liver enzymes, also require more research to exclude the potential influence of AEDs, such as clobazam and valproate. Status epilepticus, the most common severe adverse effect, was not clearly related to CBD because a large proportion of the enrolled patients had refractory epilepsy syndromes, such as LGS, DS and IS.
CBD not only has potential therapeutic effects on epilepsy, but may also be effective in treating various other neurological problems. This should be a focus of future studies. One of the most significant limitations of previous studies is their open-label, uncontrolled design and the use surveys. Future research should use blinded, randomized, controlled trials to confirm the efficacy and adverse effects without bias. Further studies of other epilepsy syndromes are also needed in future.
It must be borne in mind that CBD is still illegal in many contexts.
FDA Approves CBD-Based Drug to Treat Seizures
Although the use of cannabis has been reported for centuries, evidence in its usefulness in the treatment of epilepsy has been mainly. UAB's study of CBD oil for intractable epilepsy, funded by the State of seizure frequency and severity in patients with treatment-resistant epilepsy. receive CBD in the near future, it also provides all patients with epilepsy an. CBD also interacts with some other seizure medicines. (cannabidiol, CBD) oral solution for the treatment of seizures associated with two epilepsy syndromes.