Cannabinoid What they more they Cannabidiol & sell Review ⋆ Who Life Profile. are.

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20.06.2018

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  • Cannabinoid What they more they Cannabidiol & sell Review ⋆ Who Life Profile. are.
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    Test tube studies sugget that THC and another cannabis-derived compound slow the spread of cervical cancer. The findings add to the fast-growing number of animal and cell-culture studies showing different and direct anticancer effects for cannabinoids, chemical compounds derived from cannabis. A myriad of studies have proven many times over that cannabis is very helpful by being an antiemetic medicine in those who have undergone chemotherapy.

    Studies have confirmed the usefulness of THC in patients whose chemotherapy-induced nausea and vomiting is refractory to other standard antiemetics. A new study out of Thailand demonstrates that THC can fight cholangiocarcinoma — cancer of the bile duct. New research has shown that JWH, a synthetic cannabidiol derived from cannabis has helped mice with cocaine withdrawal.

    JWH stimulates CB2 receptors located in the brains of both mice and humans. Preclinical research shows that cannabinoid cell surface receptor CB1 plays a tumor-suppressing role in human colorectal cancer, scientists report in the Aug. CB1 is well-established for relieving pain and nausea, elevating mood and stimulating appetite by serving as a docking station for the cannabinoid group of signaling molecules. It now may serve as a new path for cancer prevention or treatment.

    Treating mice that had the CB1 receptor with an endocannabinoid agonist resulted in a decline in polyps ranging from The reduction was greater for larger polyps. CB1 thwarts survivin, a protein that protects cancer. Cannabinoids previously had been shown to kill cancer cells in lab experiments by inducing apoptosis — programmed cell death. The team confirmed the role of CB1 in apoptosis, showing that tumor cells with high CB1 expression were sensitive to apoptosis when treated by a cannabinoid agonist.

    Cell lines with silenced CB1 resisted cell death. A series of experiments showed that CB1 increases cancer cell death by stifling a protein called survivin. Survivin is overexpressed in nearly every human tumor but is barely detectable in normal tissue. Tetrahydrocannabinol THC , the main psychoactive chemical found in cannabis, has a well known effect on the brain.

    But it also latches onto the nerve cells in the upper airways of mammals and short-circuits the signals that cause coughing spasms. However, such a development is not necessary since cannabis provides this treatment already.

    The Journal of Cannabis in Clinical Practice. Previous trials in animals have demonstrated that the activation of cannabinoid receptors in the gastrointestinal tract protects the body from inflammation and modulates gastric secretions and intestinal motility, among other functions. In fact, historically, cannabis was smoked in India and China centuries ago for its gastrointestinal properties.

    They suggest the compound causes nerve cells to regenerate. The Journal of Clinical Investigation study showed rats given a cannabinoid were less anxious and less depressed. McGill University in Montreal found that cannabinoids elicit antidepressant-like behavior and activate serotonergic neurons through the medial prefrontal cortex.

    Preclinical and clinical studies by the university show that cannabis modulates mood and possesses antidepressant-like properties, mediated by the agonistic activity of cannabinoids on central CB1 receptors.

    Studies indicate cannabidiol, a cannabis compound, works as a consummate multi-tasker to protect the eye from growing a plethora of leaky blood vessels, the hallmark of diabetic retinopathy, says Dr. Liou, molecular biologist at the Medical College of Georgia. Cannabidiol, an antioxidant, may help save the retina from blindness caused by diabetes. Test-tube studies by others, as well as Dr. Number two, it inhibits the self-destructive system and allows the self-produced endogenous cannabinoids to stay there longer by inhibiting the enzyme that destroys them.

    Cannabidiols help save the neuron and, at the same time, make sure the microglial cells stay in microglial form. How good do you want a drug to be? These studies have been published in the American Journal of Pathology. He hopes the compound in cannabis may one day be given along with insulin to stop the early changes that set the stage for damaged or destroyed vision.

    Another study in Jerusalem discovered that administration of the non-psychoactive cannabinoid cannabidiol CBD lowers incidence of diabetes in animals and may be able to prevent human type 1 diabetes, according to preclinical findings. Smoking cannabis completely eliminated pain and improved symptoms of dystonia in a year-old chronic pain patient, according to findings of a case study published in The Journal of Pain and Symptom Management. After using cannabis, the patient did not require any analgesic medication for the following 48 hours.

    Clinical studies as well as anecdotal evidence demonstrate that cannabis is able to control seizures. Researchers from Germany found that natural brain chemicals which resemble cannabis extracts can interrupt a process which can trigger a seizure. Using cannabis for epilepsy is nothing new. There are reports dating from the 15th century talking about the use of cannabis to ease the symptoms of epilepsy.

    Cannabis use may confer health benefits by lowering overall body temperature, according to Tod Mikuriya, MD. Clinically, cannabis appears to actually lower temperature, which can help those with fevers.

    The results of a study published in the Journal of Pharmacology And Experimental Therapeutics show that cannabinoids interact with systemic bacterial LPS injection and indicate a role of the CB1 receptor subtype in the pathogenesis of LPS fever. Oral administration of THC significantly reduces both chronic and experimentally induced pain in patients with fibromyalgia, according to clinical trial data to be published in the June issue of the journal Current Medical Research and Opinion.

    Significant success has been demonstrated in alleviating the symptoms of glaucoma by orally administering to glaucoma sufferers a therapeutically effective, but sub-psychotropic dose of tetrahydrocannabinol THC , which is the most active ingredient in cannabis. In rats heart failure develops within 12 weeks after a big cardiac infarction. Scientists of the University of Wurzburg in Germany found out that daily application of the synthetic cannabinoid HU after the infarction prevented the drop of blood pressure left-ventricular systolic pressure and dysfunction of the arteries endothelial dysfunction.

    Cannabis use has been found to improve retention and virological outcomes in patients treated for hepatitis C. The University of South Florida College of Medicine scientists reported that the compound THC in cannabis may block the spread of several forms of cancer causing herpes viruses.

    THC acts specifically on gamma herpes viruses. The chemical had no effect on another related virus, herpes simplex-1, which causes cold sores and genital herpes.

    Two American medical doctors report the use of marijuana to cure persistent intractable hiccups in an AIDS patient. Following surgery he developed intractable hiccups. Eight days after surgery the patient who had not previously smoked marijuana did so with the result that the hiccups stopped. They recurred the next day, but disappeared permanently on the next day when he again smoked marijuana.

    The doctors conclude that marijuana may be effective in stopping hiccups untreatable by other means. There is significant evidence that cannabinoids may be involved in the modulation of pain, especially of neuropathic origin.

    HIV-related painful peripheral neuropathy is a significant medical problem with unsatisfactory treatment options. Based on the effects of cannabinoids in pre-clinical models of neuropathic pain and anecdotal case reports. A controlled trial of smoked cannabis was conducted to verify these claims. A new method for lowering blood pressure hypertension through use of a compound that synthesizes a cannabis hashish plant component has been developed by a pharmacology Ph.

    The cannabis plant,through its chemical compounds called cannabinoids, has been shown to have a beneficial, hypotensive effect. Tt was found that the cannabis compound reduced blood pressure when administered to the rats in relatively low doses. Additional testing also showed that the compound also brought about another beneficial effect, which was the relaxation of the blood vessels.

    Their condition had been slowly progressive and unresponsive to prior therapy with neuroleptics. Orally administered cannabis was initiated at mg per day and increased 1 week later to mg per day for the next 3 weeks.

    Except for transient, mild hypotension, no side effects were recorded, and laboratory tests were normal. The withdrawal of cannabis after 48 hours resulted in return of choreic movements to the pre-cannabis treatment state. The associations between use of cannabis and better lung function was found in a population-based cohort.

    Cannabis and tobacco use were reported at ages 18, 21, 26, and 32 years. Spirometry, plethysmography, and carbon monoxide transfer factor were measured at age Associations between lung function and exposure to each substance were adjusted for exposure to the other substance. Cumulative cannabis use was associated with higher forced vital capacity, total lung capacity, functional residual capacity, and residual volume. Cannabis was also associated with higher airways resistance but not with forced expiratory volume in 1 second, forced expiratory ratio, or transfer factor.

    These findings were similar amongst those who did not smoke tobacco. By contrast, tobacco use was associated with lower forced expiratory volume in 1 second, lower forced expiratory ratio, lower transfer factor, and higher static lung volumes, but not with airways resistance. Cannabis appears to have different effects on lung function to those of tobacco. Cannabis use was associated with higher lung volumes suggesting hyperinflation and increased large-airways resistance.

    There was little evidence for airflow obstruction or impairment of gas transfer. A compound found in cannabis, as well as in herbs such as basil and oregano, could help to treat inflammatory bowel diseases, Swiss scientists believe. E -beta-caryophyllene BCP is an aromatic sesquiterpene that has used for many years as a food additive because of its peppery flavor. The compound is the only product identified in nature that activates CB2 selectively. According to Gretsch, BCP is potent enough to have an impact at normal dietary levels.

    The team screened a whole library of natural products for cannabinoid activity, which led finally to fractionation of Cannibis sativa essential oil and identification of BCP as the active component. Birgit Kraft, who studies the therapeutic effects of cannabis at the Medical University of Vienna, says selective CB2 agonists are keenly sought after by clinicians, as they may be candidates for treatment of inflammatory bowel disease. In a study published in the February issue of Blood , Dr.

    Wai Man Liu and colleagues at St. Liu and his team have begun to uncover the mechanism by which THC kills those cells and potentially promotes longer-term survival. In another study, US scientists who found out that exposure of leukaemia cells to CBD led to a reduction in cell viability and induction of apoptosis. In living animals CBD caused a reduction in number of leukaemia cells. The active compound in cannabis THC can slow the growth of lung tumors and reduce the spread of the cancer in mice.

    In a study done recently, human lung cancer tumors grew less than half as fast in mice that received moderate doses of the compound. Ramesh Ganju at the Harvard Cancer Center in Boston, Massachusetts, US, and colleagues deposited human lung cancer cells under the skin of a dozen mice and allowed the tumors to grow in the animals for about two weeks. They then began giving half of these mice daily injections of about micrograms of synthetic THC right next to the tumors for three weeks.

    A cannabis cigarette may contain as much as milligrams of THC, indicating that even a microdose can have visible anti-cancer effects. Tumors in the control mice averaged about 0. By comparison, those in the mice that received THC weighed just 0. THC and other cannabinoids induce apoptosis in murine tumors of immune origin, according to researchers at Virginia Commonwealth University in Richmond.

    In a series of in vitro experiments, Dr. Nagarkatti and her colleagues exposed murine lymphoma and mastocytoma cells to four cannabinoid receptor agonists. THC and two of the others significantly reduced cell viability and increased apoptosis. In vivo experiments confirmed the effect of THC.

    Ten days after mice were injected with lymphoma cells, cells collected from animals treated with the highest dose of THC showed The research group also demonstrated that three human leukemia and lymphoma cell lines expressed CB2 and not CB1. Three cannabinoids, including THC, induced apoptosis in these cell lines in vitro, and THC showed the same effect when cultured with cells from patients diagnosed with acute lymphoblastic leukemia.

    According to basic research of scientists of the National Centre for Scientific Research in Valbonne, France, cannabidiol CBD , a compound found in cannabis, may prevent the development of prion diseases, the most known being BSE bovine spongiforme enzephalopathy , which is often called mad cow disease. It is believed that the BSE may be transmitted to human beings. In humans, it is known as Creutzfeldt-Jakob disease. CBD inhibited the accumulation of prion proteins in both mouse and sheep prion- infected cells.

    Moreover, after infection with mouse scrapie, a prion disease, CBD limited accumulation of the prion protein in the brain and significantly increased the survival time of infected mice. CBD inhibited the nerve damaging effects of prions in a concentration-dependent manner. Cannabis was listed in the United States Pharmacopeia from to as being a medical treatment for the prevention and relief of migraine headaches.

    Historical information shows that Cannabis was held in high regard for the treatment of migraine by American and British physicians for at least eight decades, from the latter half of the 19th century until the early s.

    Although no modern clinical studies have specifically investigated the use of Cannabis in migraine, a number of small pain-relief studies have reported positive results in chronic headache pain and improvement of pain tolerance. A study investigating the effects of oral doses of the Cannabis compound deltatetrahydro-cannabinol THC in patients with cancer demonstrated a trend toward pain relief with escalating doses.

    The analgesic properties of Cannabis are believed to be unrelated to opioid mechanisms. Recent studies have pointed out some possible mechanisms of action for cannabinoids in migraine, including antinociceptive effects interference with pain transmission in an area of the brain that is considered a likely area for migraine generation. Cannabis has been used therapeutically to mitigate pregnancy-induced nausea and vomiting.

    Cannabinoids possess neuroprotective properties and may modify the progression of multiple sclerosis MS , according to a review published in the journal Current Pharmaceutical Design. Investigators at the London School of Medicine, Neuroscience Center reported that cannabinoids likely hold therapeutic value for MS patients beyond providing temporary symptomatic relief.

    Therefore cannabinoids may not only offer symptom control but may also slow the neurodegenerative disease progression that ultimately leads to the accumulation of disability. There are several studies that have shown that cannabis or specific compounds in cannabis significantly decreases nausea. Furthermore, THC may relax the colon and reduce stomach cramping after eating, according to a study presented at the 71st Annual Scientific Meeting of the American College of Gastroenterology.

    The study compared the effects of dronabinol THC and placebo on colonic motility and sensation in healthy adults. The researchers found that THC relaxes the colon and reduces post-eating contractions and cramping. Further, the effects were most pronounced in females. The growing body of evidence that cannabis is effective as a pain reliever has been expanded with publication of a new study in The Journal of Pain , reporting that patients with nerve pain showed reduced pain intensity from smoking cannabis.

    Researchers at University of California Davis examined whether marijuana produces analgesia for patients with neuropathic pain. Thirty-eight patients were examined. The authors reported that identical levels of analgesia were produced at each cumulative dose level by both concentrations of the agent.

    As with opioids, cannabis does not rely on a relaxing or tranquilizing effect, but reduces the core component of nociception and the emotional aspect of the pain experience to an equal degree. Smoking cannabis helps relieve pain in patients with HIV-related neuropathy, a form of nerve damage that leads to burning and tingling sensations, which can be difficult to treat with traditional medications.

    Ellis and colleagues compared cannabis to a placebo in 28 patients with HIV-related neuropathic pain that was not adequately controlled by pain medications, including opioids. The National Institute on Drug Abuse supplied both products. The participants smoked the material four times a day for five straight days, then abstained for two weeks, and then followed the same experiment again.

    Each person also continued to take prescribed painkillers during the trial. Smoking the cannabis provided much greater pain relief than smoking the placebo. The findings, which appear online in the journal Neuropsychopharmacology , add to a growing body of evidence that shows that cannabis can be a potent painkiller for patients with neuropathy. Studies reveal that cannabis protects against brain damage from stroke, heart attacks, and nerve gas.

    Experiments with rat nerve cells, and then with actual rats, suggest that THC and cannabidiol, both compounds found in cannabis, can protect cells by acting as antioxidants, and could be useful in the treatment and prevention of stroke, heart attacks, and neurodegenerative diseases.

    The endocannabinoid system plays a significant role in skeletal remodeling the process whereby old bone is removed and new bone is added and is an ideal target for anti-osteoporotic drug development, according to a review in the journal Annals of the New York Academy of Sciences. Investigators at the Bone Laboratory of the Hebrew University in Jerusalem report that the activation of the CB2 cannabinoid receptor reduces experimentally-induced bone loss and stimulates bone formation.

    Investigators had previously reported that mice deficient in CB2 receptors exhibit markedly accelerated age-related bone loss osteoporosis. A study found that cannabinoid receptors are expressed in human pancreatic tumor cell lines and tumor biopsies at much higher levels than in normal pancreatic tissue. Studies conducted with MiaPaCa2 and Panc1 cell lines showed that cannabinoid administration induced apoptosis, increased ceramide levels, and up-regulated mRNA levels of the stress protein p8.

    Cannabinoids also reduced the growth of tumor cells in two animal models of pancreatic cancer. In addition, cannabinoid treatment inhibited the spreading of pancreatic tumor cells.

    Moreover, cannabinoid administration selectively increased apoptosis and TRB3 expression in pancreatic tumor cells but not in normal tissue. Most had used it orally, either as fresh or dried leaves. The respondents reported that the improvement in symptoms occurred an average of 1. Patients who used it for at least three months were more likely to experience symptom relief than those with shorter experience.

    In treating PTSD, cannabis provides control and amelioration of chronic stressors without adverse side effects. The modulation of emotional response relieves the flooding of negative affect. The skeletal and smooth muscle relaxation decreases the sympathetic nervous reactivity and kindling component of agitation.

    The fear of loss of control diminishes as episodes of agitation and feeling overwhelmed are lessened. Experiences of control then come to prevail. Thinking is freed from attachment to the past and permitted to fix on the present and future. Instead of being transfixed by nightmares, the sufferer is freed to realize dreams.

    Based on both safety and efficacy, cannabis should be considered first in the treatment of post-traumatic stress disorder. Contrary to the popular belief that cannabis kills brain cells, a study has shown that one of the compounds in the cannabis plant is an active ingredient that facilitates the production of new brain cells. A study by Xia Zhang and colleagues from University of Saskatchewan in Saskatoon, Canada, found that rats getting regular doses of an artificial version of a potent cannabis ingredient grew new brain cells faster than other rats.

    They found that HU a synthetic drug that is about one-hundred times as powerful as THC seemed to induce new brain cell growth, just as some antidepressant drugs do, they report in the Journal of Clinical Investigation. Ohio State University scientists have found that specific elements of cannabis can stimulate the formation of new brain cells. A recent study showed that expression levels of both cannabinoid receptors, CB1 and CB2, are significantly higher in CA-human papillomavirus virally transformed cells derived from adenocarcinoma of human prostate tissue , and other human prostate cells than in human prostate epithelial and virally transformed cells derived from normal human prostate tissue.

    It was observed that there was an induction of apoptosis, a decrease in protein and mRNA expression of androgen receptor, a decrease in intracellular protein and mRNA expression of prostate-specific antigen, a decrease in secreted prostate-specific antigen levels, and decrease in protein expression of proliferation cell nuclear antigen and vascular endothelial growth factor. The results suggest that cannabis can be an effective treatment for prostate cancer.

    Further research has found that chemicals in the cannabis plant have been found to stop prostate cancer cells from growing in the laboratory. After working initially with human cancer cell lines, Ines Diaz-Laviada and colleagues from the University of Alcala in Madrid also tested one compound on mice and discovered it produced a significant reduction in tumor growth.

    The cannabinoids tested by the Spanish team are thought to work against prostate cancer because they block a receptor, or molecular doorway, on the surface of tumour cells. This stops them from dividing. A compound derived from the cannabis plant protects blood vessels from dangerous clogging, a study of mice has shown.

    The discovery could lead to new drugs to ward off heart disease and stroke. The compound, called deltatetrahydrocannabinol THC , combats the blood-vessel disease atherosclerosis in mice. This disease occurs when damage to blood vessels, by nicotine from cigarettes, for example, causes an immune response that leads to the formation of fatty deposits in arteries.

    These deposits form because the immune cells can linger too long, recruiting others and leading to an inflamed blockage that snares fatty molecules. The disease is the leading cause of heart disease and stroke in the developed world. The compound binds to a protein called CB2 that is present on the surfaces of certain immune cells. Patients diagnosed with schizophrenia report obtaining subjective relief from cannabis to control various symptoms associated with the disease, according to survey data published in the International Journal of Mental Health Nursing.

    Contrary to some other studies about cannabis and schizophrenia, Dr. A study in the Department of Medicine in the University of Illinois at Chicago found that potent suppression of sleep-related apnea is possible by both exogenous and endogenous cannabinoids found in the cannabis plant. The data show that delta9THC and oleamide each stabilized respiration during all sleep stages. Oleamide produced equivalent apnea suppression. This observation suggests an important role for endocannabinoids in maintaining autonomic stability during sleep.

    Twenty-four patients participated in the double-blind placebo-controlled trial over a period of six weeks. Treatment with up to 10 mg of THC resulted in significant improvement of tic severity, authors wrote.

    No serious adverse effects to the treatment were reported. There has been understandable concern that, when ingested by smoking, cannabis will produce as many carcinogens has tobacco smoking. Tobacco has been shown to have either the same amount or less carcinogens in its smoke than cannabis does depending on what study is read , yet not a single death has ever been attributed to smoking cannabis, but 5,, people die ever year because of tobacco-related reasons.

    The question now stands as being: How can cannabis have hundreds of carcinogens and yet not be a cause for a single death or ever a single instance of lung cancer? The answer comes in the anti-cancer properties of the cannabinols in the cannabis. Any cancer cells that may be created by smoking the cannabis are immediately attacked by this compound, thus neutralizing the carcinogenic chemicals.

    This is also the suggestible why individuals who smoked tobacco for years, along with cannabis, have shown no signs of lung cancer. The cancer-promoting effects of smoke are increased by nicotine, while they are reduced by THC.

    Individuals who smoke cannabis do not appear to be at increased risk for developing lung cancer, according to new research. While a clear increase in cancer risk was seen among cigarette smokers in this particular study, no such association was seen for regular cannabis users.

    Even very heavy, long-term cannabis users who had smoked more than 22, joints over a lifetime seemed to have no greater risk than infrequent cannabis users or nonusers.

    The study population was limited to people who were younger than 60 because people older than that would probably not have used cannabis in their teens and early adult years. A total of lung cancer patients living in Los Angeles County, and patients with other cancers of the head and neck were compared with 1, people without cancer matched for age, sex, and the neighborhood they lived in.

    All the participants were asked about lifetime use of cannabis, tobacco, and alcohol, as well as other drugs, their diets, occupation, family history of lung cancer, and socioeconomic status. The heaviest cannabis users in the study had smoked more than 22, joints, while moderately heavy smokers had smoked between 11, and 22, joints. While two-pack-a-day or more cigarette smokers were found to have a fold increase in lung cancer risk, no elevation in risk was seen for even the very heaviest cannabis smokers.

    The more tobacco a person smoked, the greater their risk of developing lung cancer and other cancers of the head and neck. However, the reason why there is no increased risk in developing cancer might have something to do with tetrahydrocannabinol, or THC, which is a chemical found in cannabis smoke. Cellular studies and even some studies in animal models suggest that THC has anti-tumor properties, either by encouraging the death of genetically damaged cells that can become cancerous or by restricting the development of the blood supply that feeds tumors, Tashkin tells WebMD.

    University of Colorado molecular biologist Robert Melamede, PhD, concluded that the THC in cannabis seems to lessen the tumor-promoting properties of cannabis smoke. The nicotine in tobacco has been shown to inhibit the destruction of cancer-causing cells, Melamede tells WebMD. THC does not appear to do this and may even do the opposite. When we balance the autonomic nervous system, there is an effect on the mind that is both energizing and relaxing simultaneously.

    In other words, we can think more clearly and more efficiently. The following are excerpts from The Benefits of Marijuana:. Natural feelings of expansion that correspond to favorable perceptions, such as a sense of accomplishment, are experiences common to us all, What makes marijuana unique and beneficial is its ability to summon these states of well-being at will.

    When used over a period of time, it allows us to witness our many subtle motives which, under normal consciousness, are usually not noticeable. And feelings of health and happiness naturally lead to hope, which of itself can be curative. Marijuana can act as the loosening agent, so that whatever has been banned from consciousness may come cascading forth. To uncover our deceptions without our usual rationalizations can be unpleasant, an experience that has turned many psychologically fragile individuals away from marijuana despite its therapeutic catharsis.

    Regardless of the model used, marijuana resolves conflict by de-emphasizing extreme aggressiveness and stroking the receptive sides of human nature. This unification or balance, however, may be responsible for changes in goals and values. It Is the healthy balancing nature of marijuana that is most beneficial to the individual and most threatening to modern society.

    When it first became popular in the West, marijuana was imported mainly from tropical zones, where the sativa strain of cannabis is indigenous. No studies concerning the different effects of sativa vs. This is compatible with the notion that in hotter climates, less calming is desirable from a recreational substance, since hot climates in themselves cause lethargy. Many connoisseurs of marijuana prefer the sativa high, although in the last decade it has become very scarce due to domestic cultivation of strains that thrive in temperate zones and indoors.

    In relationships, a cerebral high attunes the participants to a less separate sense of themselves. Conversation is animated and a general feeling of camaraderie is in the air. Rather than freedom in the mind, the felt sensation is freedom of the body. This state more closely mimics deep relaxation. While thinking may be diminished, more sensitivity to nonverbal experiences, such as music and color, comes into play. Participants often become quieter, since internal silence predominates.

    Indica thrives in temperate areas, and as such it has become more popular with the American marijuana farmer. It is a shorter variety, thus it is more suited for the limits of indoor gardens and comes to fruition earlier in outdoor gardens. In less tropical zones, recreational substances are compatible with tempering the bustle usual to cooler climate cultures. As horticultural interest has grown, a cross between the indica and sativa species of cannabis has given the modern marijuana user the subtleties of both strains.

    Nowadays quality marijuana, grown in the US, is usually a hybrid of the indica and sativa varieties. Marijuana will not tolerate repression. Alcoholism is an extreme need of both the body and personality periodically to release the nervousness that has accumulated and continues to accumulate to an unbearable degree. It serves the same function for the collective personality for the society, as well A culture in which alcohol and tranquilizers are the prevalent form of release prefers not to witness internal confusion and actually choose to act without conscious participation, maintaining a semi-numb condition.

    Cannabis has the ability to significantly increase the creative process and facilitate it. It is largely understood that cannabis is the reason for the majority of the arts that exist today, be they music, art, film, poems, books, or other artistic expressions. To use the example of music as a form of creative expression, in order to derive meaning from music, one must learn to associate musical materials the tunes, the rhythms, the forms with super-personal realities — realities for which there are no literally articulated referents.

    Everybody likes to climb out of their own skin once in awhile and wander through the shadowy corridors of self; we like to do this because we know that a significant part of our multi-dimensional Self lives in those dark hallways as much as in the sun of rational consciousness. To illustrate the point of heightened creativity, still using the example of musical harmonics, one of the effects of cannabis on musical perception has to do with how our time perception of reality is altered: Musical events seem to pass by at a much more leisurely rate, giving a chance to notice all sorts of details which were missed during a situation in which no cannabis was utilized.

    There is also a higher level of integration of these details into a holistic musical identity which resonates with deeper human significance. Somehow the abstract mind state while experiencing cannabis can take in material that can barely scratch the surface of literal consciousness. All the physical senses are aroused by cannabis such that the experience of all the sensual aspects of music is enhanced — the formal or rhythmic sensation, neuro-motor responses, and, particularly, the sensitivity to sound quality.

    The collective artifacts in a piece of creative expression are imbued with an archetypal resonance; but during the a cannabis experience, especially since time is perceived as being decelerated, the subject is allowed to respond on a deeper level to the archetypes, and, furthermore, to make literal connections between the symbols and abstract philosophical or spiritual issues.

    The spiritual benefits can be thought of in terms of how they have an impact on consciousness. In these times of secular values, when the life force is not recognized as being an expression of The Source , or the collective consciousness of all that is, where in many instances the notion of a plane of existence beyond the material is not acknowledged as real as the dimension of space-time, the search for meaning nevertheless perseveres. In the present point in linear time, many of those that pursue the journey inward, as well as those that wish to experience Self-Realization, find that the cannabis plant is able to help with this search.

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    astvitaliy

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    toekk1

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