I am fully aware that the Hemp oil required needs to have high content not a gvax.info can get C B D oil at Holland and Barrat which is legal. know whether cannabis or cannabinoids are an effective cancer treatment. Cannabis oil for cancer treatments is provided by CBD International. Our treatment has helped thousands of cancer patients with their condition!. Currently, cannabis plant is heralded to be the natural cure for cancer. Many people have been using cannabis oil or CBD oil for cancer treatment.
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Taking cannabis could also potentially interfere with other cancer treatments given to you by a doctor, and can carry other side effects and risks. Medical cannabis in all its variants seems to be great at alleviating pain, nausea and several other symptoms BUT in the four years that I've had cancer and been researching this with a vigour that only us desperate cancer patients have, I have yet to read any research that supports its use as a cure for Cancer.
By all means use it to supplement your treatment but please don't put all your eggs into this particular basket until there is peer reviewed evidence that categorically shows that cannabinoid treatments are effective. These guys cover this far more eloquently than I do! I agree with what you say - my 'overwhelming evidence of a therapeutic effect' is your 'Medical cannabis in all its variants seems to be great at alleviating pain, nausea and several other symptoms' - I made no suggestion of cure or 'treatment', merely that it had an 'evidenced' effect, mostly anecdotal.
I had a couple of different oils bought for me just after diagnosis by sons convinced it could be helpful. I took none of it. Because I didn't know how it would interact with the conventional treatment I was on, because the dosage was unknown and because the ingredients were unknown.
Morally, I had no problem. Similarly, I don't dose myself with tumeric or circumin, despite my sister claiming it cured her dogs tumours. I don't have a special diet or drink 'juices'. I don't believe prayer will have an effect. I've reported a couple of charlatans on this site and their posts were removed. I have no truck with anybody trying to influence the vulnerable, to sell them oils or alternative rubbish.
Fair enough, I must have misunderstood what you were saying. I suggest though that the mass of anecdotal stuff was the impetus for the research that ended up with various medicinal cannabis drugs, which must surely be now classed as conventional.
If you're going to prove or not that something has a clinical effect then you have to do the clinical trials and collect the data in scientific and repeatable manner. What you can't do is trawl the web, count the hits, and claim that proves the case. As a prostate cancer patient, I've been following the so-called effect of Pomegranate Juice as a treatment for prostate cancer. Those web pages touting this "cure" will be online for years to come, and I'm sure plenty of men will gain false hope when they read them.
I absolutely agree with you Tele and I didn't mean to suggest that anecdotes were data. Personally, I ignore all anecdotal stuff. I've noticed loads of it as you have and I'm fascinated by peoples' gullibility. The way some will immediately take the word of one random stranger on the internet in preference to clinical data.
Having said all that, 'clinical stuff' has found that there's something to be said for cannabis, though there's a lot more researching to do. I've merely said that the mass of anecdotal stuff about cannabis is probably what gave impetus to initial research. I'm inherently lazy; I'll probably go along with whatever the docs recommend until such time as I'm unable to cope with it.
As someone who can't have chemo or radio because my skin does not heal well and still going through operations to heal my scar from mastectomy 9 months ago I know these things are NO cure Sadly I have met people who claim cannabis cures cancer. This has happened more than once too. Phytocannabinoids are secondary metabolites of Cannabis plants. Action of THC in human organism relies on mimicking endogenous agonists of CB receptors—endocannabinoids 3. Another phytocannabinoid which gains medical attention is cannabidiol CBD.
It has low affinity for cannabinoid receptors and acts independently of them. They have been proposed to be classified as CB receptors, but their exact role in endocannabinoid signaling is still under discussion 3.
Endocannabinoids are part of the endocannabinoid system, which is composed of cannabinoid receptors, their endogenous ligands, and the enzymes involved in their metabolism. To date, two cannabinoid receptors CB1 and CB2 have been identified in mammalian tissues 5 , 6.
Its high expression has been observed in these areas of central nervous system, that are engaged in the modulation of motor behavior, memory, learning, emotions, perception, and endocrine functions 3 , 8.
CB2 receptors have been found in immune cells, but their presence was revealed also in nervous system 10 , In addition to its neuromodulatory function, endocannabinoid system has been shown to play other important functions such as control of the energy metabolism, immunity, cardiovascular tone, and reproduction 12 , According to the contribution of the endocannabinoid system in a regulation of such variety of processes, its pharmacological modulation becomes promising therapeutic strategy.
To date, cannabinoids have been exploited in the palliative medicine. Nabilone THC synthetic analogue is allowed for the treatment of nausea and vomiting induced by chemotherapy, and sleep disorders. Dronabinol synthetic THC is approved also for nausea and vomiting due to chemotherapy and for the treatment of weight loss associated with AIDS. Medical Cannabis in the form of marijuana dried flowers and leafs is illegal in the USA at the federal level according to the Controlled Substances Act as a Schedule I substance, but some states have legalized it for medical purposes Besides palliative properties of cannabinoids, it has been shown in wide range of in vitro and animal models, that they also exhibit anticancer effects 7 , 15 , 16 , Despite numerous studies conducted during the last decade, there are still inconsistent data regarding the exact role of cannabinoid system in cancer development.
The upregulated expression of CB receptors and the elevated levels of endocannabinoids have been observed in a variety of cancer cells skin, prostate, and colon cancer, hepatocellular carcinoma, endometrial sarcoma, glioblastoma multiforme, meningioma and pituitary adenoma, Hodgkin lymphoma, chemically induced hepatocarcinoma, mantel cell lymphoma , but it is not always correlated with the expression level of these receptors in tissue of origin 7 , 11 , 18 , Furthermore, concentration of endocannabinoids, expression level of their receptors, and the enzymes involved in their metabolism frequently are associated with an aggressiveness of cancer.
This implies that an overactivation of endocannabinoid system might be protumorigenic and plays an essential role in the development of cancer 20 , On the other hand, there are reports indicating that an activation of the cannabinoid receptors can impair cancer development and hence endocannabinoid signaling can be antitumorigenic. Furthermore, it has been shown that silenced expression of CB1 receptor leads to an acceleration of intestinal adenoma growth, whereas activation of this receptor attenuates its growth in murine model The elevated level of endocannabinoids has been shown to reduce the development of precancerous lesions in mouse colon On the other hand, there are reports that have indicated that under certain circumstances, cannabinoids can be protumorigenic 31 , 32 , It has been shown that CB1 and CB2 receptor agonists stimulate apoptotic cell death in glioma cells by induction of de novo synthesis of ceramide, sphingolipid with proapoptotic activity 34 , If this response fails, ER stress can lead to activation of intrinsic apoptosis pathway The known mechanisms responsible for the induction of apoptosis by cannabinoids.
It has been demonstrated that process of autophagy is upstream of apoptosis in mechanism of cell death induced by cannabinoids. An inhibition of autophagy prevents apoptosis induced by cannabinoids, while an inhibition of apoptosis prevents only cell death but not the autophagy 39 , 41 , 42 , It has been shown that cannabinoids induce process of autophagy in cancer cell lines such as glioma, melanoma, hepatic, and pancreatic cancer 39 , 41 , 42 , Moreover, some additional mechanisms have been demonstrated to contribute to the process of an induction of cell death by cannabinoids in certain cell lines.
Similar results have been obtained in prostate carcinoma cells Table S1 Cannabinoids devoid of psychoactive properties also exhibit anticancer potential. They do not affect CB receptors directly and their exact mechanism of action is still not fully elucidated. Another interesting explanation is that CBD can prevent the degradation of anandamide AEA and subsequently leads to increased endocannabinoid concentration by acting as an inhibitor of fatty acid amide hydrolase FAAH 52 , This notion raises the possibility that the observed actions of CBD can be, in fact, partially the result of an elevated level of AEA.
These observations are in line with the described earlier relations between endocannabinoids and cancer development. Most of the research implicates that the action of CBD and other cannabinoids devoid of psychoactive properties is not linked to a direct activation of the CB receptors. However, there are reports suggesting that CBD can induce apoptosis in cancer cells partially via direct or indirect activation of CB2 receptor Recent studies have shown that CBD reduces cancer cell viability in many cancer types such as neuroblastoma, glioblastoma, melanoma, leukemia, colorectal, breast, lung, or prostate cancer Table S1 41 , 50 , 51 , 54 , 56 , 57 , 58 , The mechanism of the immunomodulatory effects of cannabinoids is still not fully elucidated.
Research has been focused mainly on the CB2 receptor, mostly due to its expression primarily in cells of the immune system.
CB1 receptors have been noticed in the T lymphocytes and it is proposed that their activation may be connected with the cytokine biasing induced by cannabinoids The highest level of CB2 expression has been observed in B cells, followed by NK cells, monocytes, polymorphonuclear neutrophils, and T cells It has been shown that the expression level of CB2 correlates with the cell activation state and with the presence of immune modulators The immune system is postulated to be involved in the control of growth and development of many types of cancer.
One of the key regulators of the antitumor immune response is cytokines profile. It is postulated that a Th1 response is crucial for an effective immune response against many tumors Phytocannabinoids with high affinity for CB2 receptors, such as THC, exhibit modulatory effects on both cellular and humoral immunity.
Nonpsychotropic cannabinoids with low affinity for CB receptors have also been proven to exhibit immunomodulatory action. Most of the studies indicate that cannabinoids exhibit immunosuppressive action The most extensively examined immunomodulatory effects of cannabinoids in context of cancer are regarding the changes in the activity of T cells. It has also been proposed that cannabinoids can affect T cells by the induction of apoptosis 73 , Another possibility is that cannabinoids effects on immune cells are at least partially induced indirectly via other suppressive mechanisms such as release of cortisone The effects on the Th17 cells subsets have not been fully described to date.
Interestingly, CB receptors seem to take part in the modulation of those phenomena Indeed, there are reports indicating the suppression of anticancer immune response by THC. It has been demonstrated that THC suppresses host immune reactivity against cancer in murine lung cancer model Lewis lung carcinoma, 3LL and line 1 alveolar cell carcinoma L1C2 , leading to the increase in the tumor growth CB2 receptors antagonists also blocked the effects of THC administration.
Similar results were obtained in the study of mouse mammary carcinoma. It has been demonstrated that THC exposure leads to the significant increase in the 4T1 carcinoma growth and metastasis due to the inhibition of the specific antitumor immune response Observed effects were mediated by CB2 receptors It is possible that tumors originating from tissues of low CB receptors expression would be significantly less sensitive to cannabinoids anticancer action and, eventually, due to THC immunosuppressive properties, such tumors may find a favorable environment for growth and development.
It is also possible that anticancer properties of cannabinoids may be compensated by their immunosuppressive action, finally leading to promotion of the tumor growth.
Chronic inflammation has been associated with the development of neoplasia; therefore, reducing inflammation may, to some extent, contribute to the prevention of carcinogenesis. Viability of noncancerous cells seems to remain unchanged or sometimes even elevated by cannabinoids 34 , 35 , 36 , 39 , On the other hand, cannabinoids can trigger apoptotic cell death in some types of nontransformed cells, especially those of high proliferative properties such as endothelial cells The cellular response to cannabinoids relies on different mechanisms in cancerous and noncancerous cells.
It has been demonstrated in vitro that cannabinoids can exhibit a stimulatory activity in nanomolar concentration and an inhibitory activity in micromolar concentration biphasic response , which significantly exceeds concentrations usually detected in blood of marijuana smokers Concentration of THC used in described experiment corresponded to its serum concentration obtained by smoking or oral administration of THC Besides the above described proapoptotic effect in cancer cells, cannabinoids exhibit some other important and potentially valuable properties.
It has been demonstrated that they can inhibit angiogenesis by blocking an activation of the vascular endothelial growth factor VEGF pathway. Cannabinoids have also been shown to reduce spontaneous and induced metastases in animal models and to inhibit an invasiveness of cancer cells in vitro breast, lung, cervical cancer, and glioma 86 , 87 , 88 , 89 , These effects are partially connected with a modulation of the activity of extracellular proteases and their inhibitors 86 , The pharmacological inhibition of ceramide biosynthesis and the expression of p8 protein lead to the prevention of the mentioned effects The studies conducted to date indicate that antiangiogenic and antimetastatic characteristics of CB receptor agonists, similar to their antiproliferative effects, rely on the stimulation of ceramide biosynthesis and a modulation of pathways involving p8 protein.
Cannabinoids that are not agonists of CB receptors CBD , have also been shown to exhibit such properties. Increased levels of FAAH substrates e. Data collected to date regarding anticancer effects of cannabinoids are almost completely limited to preclinical studies conducted on cell lines and animal models.
The first experiment that was conducted on human subjects was a pilot clinical study on nine terminal patients with recurrent glioblastoma who were resistant to the standard therapy Patients received THC intratumorally.
This way of administration was safe and patients did not exhibit any overt psychoactive effects. In some patients the tumor growth rate decreased. Changes observed upon THC administration in two patients can be connected with anticancer effect of THC according to previous preclinical studies decreased cell proliferation, occurrence of apoptosis Despite these interesting observations, it is not possible to draw significant conclusions from the study on a group of nine.
This shows a need for further clinical trials, which could help to assess the dosage and the potential interaction of cannabinoids with other substances.
These studies are currently ongoing or have ended recently, but the results have not been published to date. Cannabis plants produce a substantial amount of cannabinoids and other secondary metabolites. It has been demonstrated that extracts of Cannabis exhibit stronger effects on the subjects with spasticity than pure THC Some cannabinoids have been demonstrated to attenuate psychoactive effects of THC or smoked marijuana 13 ,
The current state and future perspectives of cannabinoids in cancer biology
What's the Evidence That Hemp Could Be Useful in Treating Cancer? . CBD oil, which contain cannabinoids and can be derived from hemp. A study on mice examined the effects of THC and CBD However, the hemp oils appeared to treat her cancer, though she died a If you want to try using RSO for cancer, it's best to keep up with any other treatments. CBD oil has shown promise as a treatment for both depression and to cancer and side effects related to cancer treatment, like nausea, vomiting and pain. . Aeroflow offers premium organic, whole plant, pure hemp extracts.